Technical Services

Drug-Induced Evaluation Technical Services

I. Services Overview

Drug induction refers to the process by which pharmaceuticals activate nuclear receptors (e.g., PXR, CAR, AHR), upregulating the transcription of downstream target genes and enhancing the activity of drug-metabolizing enzymes (e.g., CYP450). This mechanism can accelerate the metabolism of the drug itself or co-administered drugs, potentially compromising therapeutic efficacy and safety. Drug induction evaluation is a critical component of drug development, assessing risks of drug-drug interactions (DDI) and informing metabolic/toxicological studies.

II. Detection Models

Primary Hepatocyte Model

Primary hepatocytes serve as the "gold standard" for in vitro drug metabolism research, closely replicating hepatic metabolic functions. They are widely used for:

• Drug induction profiling

• Toxicological studies

• DDI risk assessment

III. Detection Conditions

Liquid Chromatography-Mass Spectrometry (LC-MS/MS)

IV. Service Credentials, Facilities, and Team

• GMP-Compliant BSL-2 Lab:

• Registered with the National Health Commission for handling HBV, lentiviruses, and human/animal samples.

• Advanced Equipment (Total value: RMB 20+ million):

• Confocal microscope, fluorescence-activated cell sorter (FACS), ultracentrifuges, real-time qPCR systems.

• Expert Team:

• Ph.D., Wuhan Institute of Virology, CAS.

• 14+ years in liver research.

• Principal investigator for 7 national/provincial grants (NSFC, Guangdong DST, Shenzhen STIC).

• 10+ first/corresponding-author SCI publications.

• AIMBE Fellow, National Young Thousand Talents, and Shenzhen High-Level Talent Awardees.

VI. Case Studies

Case Study: A Xi'an Research University