Customized Mini-liver (Liver Spheroids) Service
Liver spheroids (mini-livers) are 3D-cultured micro-liver models formed through the self-assembly of primary hepatocytes or liver non-parenchymal cells. These structures replicate the three-dimensional architecture and physiological functions of liver tissue. Key advantages include the preservation of hepatocyte polarity, cell-cell communication, and enhanced expression of critical functions such as albumin synthesis, urea secretion, and drug-metabolizing enzyme activity, offering a more physiologically relevant microenvironment compared to traditional 2D cultures. By co-culturing hepatic stellate cells, endothelial cells, and other cell types, pathological processes like fibrosis or inflammation can also be modeled.
This platform is widely used for drug hepatotoxicity evaluation, pharmacokinetic studies, and research on chronic liver disease mechanisms, providing a high-throughput, cost-effective alternative to animal testing.
Technical Highlights
Rapid self-assembly: Proprietary technology utilizing ultra-low adhesion and spheroid-promoting reagents enables spheroid formation within 24 hours.
Long-term culture: Optimized culture media support spheroid viability and functionality for up to 2 months, ensuring sufficient time windows for advanced studies.
Pathological modeling: Customizable co-culture systems to mimic disease-specific microenvironments (e.g., fibrosis, inflammation).
Why Choose LV Biotech
Certified facilities: Operates in a National Health Commission-certified quasi-GMP Biosafety Level 2 (BSL-2) laboratory.
Expertise: A 14-year track record in liver research, backed by a team of specialists.
Comprehensive solutions:
Supply of high-quality primary hepatocytes, liver non-parenchymal cells, and customized liver spheroids.
End-to-end experimental support, from design to data analysis.
Expert-level technical guidance and seamless Lab-to-Lab collaboration.
Contact us to integrate liver spheroids into your research workflow and advance your drug discovery or disease modeling projects with precision and efficiency.
