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Creating liver-like tissue from spleen

发布时间:2020-06-24 17:31:50

The liver is an organ that can be transplanted from a living donor to a recipient.  The liver is capable of regeneration.  Any method that expands the supply of liver tissue ex vivo could prove useful.  

A novel experiment was performed by Wang L. et al.  A mouse spleen was modified to support the creation of spleen tissue.  Tumor extract was injected into a spleen to create a pro-generative and immuno-suppressive environment.  Liver cells were implanted, ultimately proliferating.  The source were autologous, allogeneic, and xenogeneic.  Functional tests demonstrated that the liver-like tissue embedded in the spleen were functional.  


Could these experimental set up be used to foster the growth of human liver tissue?



Wang L, Wang C, Wang Z... et. al. "Transforming the spleen into liver-like organ in vivo." Science Advances 10 Jun 2020 6(24) eaaz9974.    DOI: 10.1126/sciadv.aaz9974